The skin is responsible for 80% of the sound quality, so it is the main part of the shamisen which you have to take care of. Frequent change in humidity and temperature will weaken the skin. When you play, avoid direct sunlight on a hot day, and moist environments. Skin replacement is costly, so keeping it safe will benefit your wallet! Watch how to properly care for the skin.
Note: Synthetic skin isn’t affected by climate, so it will last much longer.